Sara Gilbert, you're not alone.
Couples break up all the time—gay and straight. So Sara, if you're feeling blue about you and your partner, television producer and writer Alison Adler, calling it quits after nine years and two children together, just know it'll be OK.
You're certainly not the first lesbian power couple to call it quits in Tinseltown.
So with that, we give you E! Online's top five lesbian breakups in Hollywood. Remember, for every Anne Heche in the world, there's also a Portia de Rossi: